The reception is oocyte assisted reproduction technique in which the female gamete (egg) is contributed by a different woman who will receive the embryo. A cycle of IVF fertilizing eggs with partner’s sperm.
Egg donation is indicated when:
- Do not have own eggs (when the patient has menopause, either naturally or secondary to medical or surgical treatments in treating tumors…).
- There is a possible risk of transmission of a hereditary disease.
- The gametes are of low quality (women over 45 years, hidden ovarian failed, previous unsuccessful IVF cycles, repeated abortions…).
In Fertilab, the maximum age to cycle oocyte reception is 50 years, provided that confirm a good state of health by the recipient.
The Spanish law authorizes and regulates egg donation by Law 14/2006 on assisted reproduction techniques and by Royal Decree 412/1996.
Donor selection is performed according to very strict medical criteria. By law, donors are young women between 18 and 35 years, with a good mental and physical health. In Fertilab we have established a maximum age of 32 years to become a donor, after assessing our results by age. We achieve optimal treatments because the average age of our donors is set 26 years.
The donor fills out a questionnaire about their background and family history, emphasizing the study those pathologies that may have a hereditary component. The candidate takes a personality test and an interview with the psychologist, and a visit to the gynecologist consisting of: physical examination, Pap smear, vaginal and cervical cultures, vaginal ultrasound, blood tests to determine blood group and karyotype testing know their hormonal status, if cystic fibrosis carrier and the absence of infectious diseases (hepatitis B and C, HIV, syphilis …).
The donor signs a consent by which agrees to donate her eggs and waive know the identity of the recipient.
The allocation of the donor is performed by the center ensuring maximum phenotypic and immunological similarity between the donor and the recipient (we guarantee the physical and blood group similarity). The only relevant information is communicated donor to the recipient is one that is important for pregnancy control (age, blood group and Rh factor).
In Fertilab, reception cycles egg can be performed synchronously or asynchronously.
The recipient and the donor cycle performed simultaneously. It is the treatment that offers more chances of success.
The donor gets treatment for ovarian stimulation by administration of gonadotrophin injections subcutaneously for two weeks. Ultrasound and analytical controls that allow us to set the day of the follicular puncture in advance performed 48-72 hours. Subsequently, oocytes to be fertilized with the sperm of the recipient couple are recovered.
In Fertilab, we believe we offer the best chance of pregnancy to our patients, so we try to get a minimum of 6-8 oocytes per cycle.
The average number of eggs per recipient in Fertilab is around 11, allows us to obtain a sufficient number of embryos to conduct a good embryo selection.
The patient receiving the treatment of endometrial performed while preparing the donor ovarian stimulation takes prepared to have the endometrium facing the implantation of the embryo transferred.
If the patient has ovarian activity before starting treatment, the patient administrate a dose of GnRH analogue to block ovulation cycle during the reception in order to coordinate the cycle with the donor.
During treatment, checks are performed by vaginal ultrasound to measure the thickness and pattern of the endometrial lining. This treatment can last two weeks. Once confirmed pregnancy, substitutive hormonal therapy is needed to carry it out until the 12th week of gestation.
The number of embryos transferred in one cycle is consensual among school professionals (biologists, physicians) and the couple. Reception cycles of eggs, usually we transfer 2 embryos at 2-3 days of the follicular puncture. However, either at the request of the couple or medical criteria (age of the recipient, pathology contraindicated multiple gestation), selective transfer of an embryo arises.
The patient is not synchronized with the donor, but the oocytes are fertilized with the partner’s sperm or with the donor’s sperm and the embryos with a good quality will be vitrified and will be transferred in a second time if the endometrium of the patient is ready.
- Receiving eggs (synchronous cycle): 61.9% per cycle.
- Receiving eggs (asynchronous cycle): 45% per cycle.