Preimplantation genetic diagnosis (PGD) is a diagnostic technique used as supplement of the in vitro fertilization that allows genetically to analyze the embryos in the early stages of their development and transfer to the uterus embryos classified as unfit (no genetic damage). The objective is to ensure healthy offspring and avoid the transmission of any disease, chromosomal abnormality or genetic mutation.

PGD requires an exhaustive study by our team of doctors, biologists and geneticists, as well as the establishment of an individualized diagnostic and therapeutic strategy. Next, the couple must undergo in vitro fertilization treatment to grow the embryos to the blastocyst stage, when we will embryo biopsy.

Embryo biopsy:

each embryo is extracted a cell to study their chromosomes. The embryos diagnosed as healthy (no chromosomal abnormalities) may be transferred to the uterus for an evolutionary and normal pregnancy.

The DGP ensures healthy offspring. Every we know more chromosomal abnormalities that cause hereditary diseases. These alterations and can be detected in the embryo. In the list of indications of subsidiaries diseases, the preimplantation genetic diagnosis, reflects all the diseases that can be diagnosed. If you are interested in obtaining information about a disease that is not on the following list, contact us. Our geneticists are in constant innovation and research.

The DGP is indicated when genetic diagnosis is technically possible, its reliability is high, the chances of success are acceptable and assisted reproduction techniques are feasible.

Indications of subsidiaries disease DGP

You can make the DGP of any genetic disease in which the gene has been characterized, regardless of their pattern of autosomal dominant inheritance, autosomal recessive or X-linked Ideally, they should be responsible mutation has been identified and that the families of the partner have been studied.

Until today, PGD has been applied to the analysis of more than 160 different monogenic diseases. The DGP is only indicated when genetic diagnosis is technically possible, its reliability is high, the chances of success are acceptable and assisted reproduction techniques are feasible.
Couples suitable for the purpose of PGD are those with a high genetic risk monogenic diseases or numerical and structural chromosome abnormalities. It is also indicated for couples from IVF programs with repeated miscarriages and repeated implantation failures. We can also indicate when the woman’s age is above 37 years and when the study of meiosis man reveals alterations.

Special indications for PGD

Predisposition to certain diseases

There are mutations in certain genes that predispose to disease in the life course. When this hereditary behavior is confirmed, the possibility of PGD will prevent the onset of disease in offspring.

Examples of these preventable diseases are familial adenomatous polyposis, neurofibromatosis, and breast cancer genetic. In these cases, PGD expressly authorized by the health authority is required, with a favorable report from the National Commission on Assisted Human Reproduction.

Preimplantation Genetic Diagnosis and histocompatibility (HLA)

The current law on assisted reproduction techniques contemplates the possibility of a PGD cycle to determine the histocompatibility antigens (human leukocyte antigen HLA-) for therapeutic purposes for third parties.

This solution applies when a first-degree relative, usually a child, suffering from a disease of hematopoiesis requiring a bone marrow transplant or umbilical cord cells. In these cases, to perform PGD expressly authorized by the health authority is required, with a favorable report from the National Commission on Assisted Human Reproduction.

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